Endocrine Abstracts

Objective: The finding of new biomarkers is needed to have an early diagnosis of breast cancer. In this study we evaluated serum levels of carboxylated osteocalcin (OC) and uncarboxylated osteocalcin(UcOC), CRP as a diagnostic biomarker for breast cancer.Design and methods: Blood samples of 39 women with newly diagnosed breast cancer with stage I were obtained before surgery and 39 age and BMI matched health women were selected as controls.<p class="...

Introduction: Thymic hyperplasia is a rare manifestation of Graves disease. In this report, we describe a female with Graves’ disease and a neck mass that was associated with thymic hyperplasia.Case report: A 28-year-old woman was referred to our division for the evaluation of palpitations. Thyroid function tests were associated with thyrotoxicosis. Thyroid receptor antibody (TRAb) was found to be 22.3 U/l (positive: >14 U/l). Sonography showed ...

Objective: Endogenous hyperthyroidism is associated with altered coagulation. The aim of the present study is to investigate the effect of levothyroxine (LT4) suppression treatment for benign thyroid nodules on coagulation system.Design: Prospective case-control study.Patients: Thirty consecutive euthyroid pre-menopausal women with nodular goitre disease and 28 healthy controls were included in the study.Meas...

Thyroid dysfunction is associated with altered levels of several coagulation factors. The aim of this study is to investigate the effect of levothyroxine suppression therapy for benign thyroid nodules on coagulation system.Thirty-six patients with benign thyroid nodules, who were applicant for levothyroxine suppression therapy, were included in the study. Thirty patients completed 1 year follow-up period. Levothyroxine was given to maintain TSH level bet...

Introduction: Malignant insulinoma is a rare functional endocrine tumor of the pancreas. Therefore, there are few data regarding their optimal therapy and long term prognosis. Malignancy is defined by the presence of metastases, mostly in lymph nodes or the liver. Generally these patients present with severe hypoglycemia and require multiple therapies. Here, we described the management of a patient with malignant insulinoma.Case: A 41-year-old woman with...

IntroductionGlucagonoma is an extremely rare type of functional pancreatic neuroendocrine tumor that is characterized by distinctive clinical manifestations such as diabetes mellitus, weight loss, deep vein thrombosis, and necrolytic migratory erythema which represents the hallmark clinical sign of glucagonoma syndrome. Here, we report the case of a 53-year-old male patient who presented with high amilase and lipase levels. In further investigation a pan...

Background: Macrofollicular variant (MV) is a rarely seen variant of papillary thyroid carcinoma (PTC). We herein present clinical characteristics of four patients carrying this variant of PTC. Case 1: 62-year-old female patient underwent total thyroidectomy (TT) due to euthyroid multinodular goiter (MNG) with a cytology of ‘indeterminate nodule’. The pathology revealed ‘papillary thyroid microcarcinoma MV with a diameter of 8×6 mm, without capsule or lymph...